Dr. B. Rijn van

Clinical Lecturer in Obstetrics and Gynaecology

University of Southampton , Academic Unit of Human Development and Health, Southampton
Verenigd Koninkrijk


Curriculum vitae

Bas B van Rijn MD PhD
Princess Anne Hospital
Mailpoint 815, Level F
Coxford Road, Southampton SO16 5YA, UK
T +44 (0)23 8079 6044


  • 1995-2000 Faculty of Medicine, Utrecht University, The Netherlands.
  • 1999 Research Elective, Dept. of Physics and Astronomy, Laboratory for Interface Physics, Faculty of Science; and Dept. of  Nephrology and Vascular Medicine, Faculty of Medicine, Utrecht University, The Netherlands (mentors: Dr. Ernst E. van Faassen and Dr. Eric S. Stroes).
  • 2000 Research Elective, The Rayne Institute for Cardiovascular Research, Guy’s and St Thomas’ Hospital, King’s College London, UK (mentors: Prof. Frank J. Kelly and Prof. Lucilla Poston).
  • 2000-2002 Clinical Rotations, University Medical Center Utrecht, The Netherlands
  • 2002 M.D., Utrecht University, The Netherlands.
  • 2002 Clinical Elective, Dept. of Ophthalmology, Hospital Kuala Lumpur, Malaysia. 
  • 2003-2005 Ob/Gyn Residency, University Medical Center Utrecht, St. Elisabeth Hospital Tilburg and St. Antonius Hospital Nieuwegein, The Netherlands.
  • 2008 Ph.D., Utrecht University, The Netherlands. 
    Title of dissertation: “Early-Onset Preeclampsia: Constitutional Factors and Consequences for Future Pregnancy Outcome and Cardiovascular Health”. Full text available at: http://igitur-archive.library.uu.nl/dissertations/2008-1203-201032/UUindex.html
  • 2012-present Clinical Lecturer in Obstetrics and Gynaecology, Academic Unit of Human Development and Health, University of Southampton (UK)



  • Dutch College of Obstetrics and Gynaecology (Ned. Ver. voor Obstetrie and Gynecologie; NVOG) – Member
  • Royal College of Obstetrics and Gynaecology (RCOG) – Postgraduate Trainee Register
  • Society for Gynecologic Investigation (SGI) – In Training Member.
  • International Society for the Study of Hypertension in Pregnancy (ISSHP) – Member.
  • International Society for Development Origins of Health and Disease – Member


Research Interests

  • Preeclampsia, fetal growth and maternal cardiovascular health
  • Epigenetics, miRNAs, maternal-fetal innate immunity and inflammation 
  • Placental pathology, spiral artery remodelling and pregnancy-related cardiovascular complications
  • Fetal cardiac and cardiovascular programming, developmental origins of heart disease


Awards and scholarships

  • 2000 Talma Eykman Award for Best Undergraduate Research Elective at Biomedical Faculties, Utrecht University.
  • 2000 Erasmus/Socrates Scholarship, Utrecht University/European Union.
  • 2003 AGIKO Stipend, 3-Year Clinical Research/PhD Scholarship, The Netherlands Organisation for Scientific Research, ZonMW #920-03-230. 


Recent Lectures at International Meetings

  • Van Rijn BB. New Insights into Developmental Origins and Consequences of Placental Dysfunction. 64th Annual SWOGS Meeting. October 2013, Winchester, UK.
  • Van Rijn BB. Cardiovascular Risk after Preeclampsia. CVOI Course on Pregnancy and Heart Disease. January 2013, Utrecht, NL.
  • Van Rijn BB, Heida KY, Veerbeek JH, Koster MP, Van der Schouw YT, Bots ML, Franx A. Pregnancy as a Cardiovascular Challenge Test: Evaluation of Hypertension and Diabetes in Pregnancy as Predictors of Cardiovascular Disease Among 15,175 Women Aged 49-70 Years. Accepted Abstract for Oral Presentation at the 60th Annual Scientific Meeting of the Society for Gynecologic Investigation (SGI). March 2012, Orlando, FL, USA.
  • Van Rijn BB. Preeclampsia: A Reproductive Manifestation of Cardiovascular Risk. NEDWEP Symposium “(Pre)eclampsia: Brain Involvement and Cardiovascular Risks”. March 2011. University Medical Center Groningen, NL.
  • Van Rijn BB, Nijdam ME, Janssen KJ, Bruinse HW, Moons KG, Bots ML, Franx A. Development of a Model for Preconceptional Prediction of Early-Onset Preeclampsia Based on Cardiovascular Risk Parameters. Accepted Abstract for Oral Presentation at the XVII World Congress of the International Society for the Study of Hypertension in Pregnancy (ISSHP). October 2010, Melbourne, Australia.
  • Van Rijn BB, Franx A, Rijkers GT, Bruinse HW. Characterization of Maternal Innate and Adaptive Inflammatory Patterns in Women with a History of Early-Onset Preeclampsia. Accepted Abstract for Oral Presentation at the 56th Annual Scientific Meeting of the Society for Gynaecologic Investigation (SGI). March 2008, San Diego, CA, USA. 


Selected Publications

  • Van Rijn BB, Veerbeek JH, Scholtens LC, Post Uiterweer ED, Koster MP, Peeters LL, Koenen SV, Bruinse HW, Franx A. C-Reactive protein and fibrinogen levels as determinants of recurrent preeclampsia: a prospective cohort study. Accepted for publication in J Hypertens. 2013.
  • Van Rijn BB, Nijdam ME, Bruinse HW, Roest M, Uiterwaal CS, Grobbee DE, Bots ML, Franx A. Cardiovascular disease risk factors in women with a history of early-onset preeclampsia. Obstet Gynecol. 2013; 121(5): 1040-8.
  • Veerbeek JH, Smit JG, Koster MP, Post Uiterweer ED, Van Rijn BB, Koenen SV, Franx A. Maternal cardiovascular risk profile after placental abruption. Hypertension. 2013; 61(6): 1297-301.
  • Kuc S, Wortelboer EJ, Van Rijn BB, Franx A, Visser GH, Schielen PC. Evaluation of 7 serum biomarkers and uterine artery Doppler ultrasound for first-trimester prediction of preeclampsia: a systematic review. Obstet Gynecol Surv. 2011; 66(4): 225-39.
  • Van Kuijk SM, Nijdam ME, Janssen KJ, Sep SJ, Peeters LL, Delahaije DH, Spaanderman M, Bruinse HW, Franx A, Bots ML, Langenveld J, van der Post J, van Rijn BB, Smits L. A model for preconceptional prediction of recurrent early-onset preeclampsia: derivation and internal validation. Reprod Sci. 2011; 18(11): 1154-9.
  • Schaaf JM, Bruinse HW, van der Leeuw-Harmsen L, Groeneveld E, Koopman C, Franx A, van Rijn BB. Reproductive outcome after early-onset pre-eclampsia. Hum Reprod. 2011;  26 (2): 391-7.
  • Veltman-Verhulst SM, van Rijn BB, Westerveld HE, Franx A, Bruinse HW, Fauser BC, Goverde AJ. Polycystic ovary syndrome and early-onset preeclampsia: reproductive  manifestations of increased cardiovascular risk. Menopause. 2010; 17 (5): 990-6.
  • Van Rijn BB, Bonestroo TJ, Roest M, Voorbij HA, Bruinse HW, Franx A. Interleukin-18 Deficiency Plays a Role in the Development of the Insulin Resistance Syndrome after Early-Onset Preeclampsia. Reprod Sci. 2010; 17(3) Suppl. 131A
  • Van Rijn BB, Franx A, Steegers EA, de Groot CJ, Bertina RM, Pasterkamp G, Voorbij HA, Bruinse HW, Roest M. Maternal TLR4 and NOD2 Gene Variants, Pro-Inflammatory Phenotype and Susceptibility to Early-Onset Preeclampsia and HELLP Syndrome. PLoS ONE. 2008; 3(4), e1865. 
  • Van Rijn BB, Franx A, Sikkema JM, van Rijn HJ, Bruinse HW, Voorbij HA. Ischemia modified albumin in normal pregnancy and preeclampsia. Hypertens Pregnancy. 2008; 27(2): 159-67.
  • Visser N, van Rijn BB, Rijkers GT, Franx A, Bruinse HW. Inflammatory changes in preeclampsia: Current understanding of the maternal innate and adaptive immune response. Review. Obstet Gynecol Surv. 2007; 62(3).
  • Van Rijn BB, Hoeks LB, Bots ML, Franx A, Bruinse HW. Outcomes of subsequent pregnancy after first pregnancy with early-onset preeclampsia. Am J Obstet Gynecol. 2006; 195(3): 723-8.
  • Van Himbergen TM, Voorbij HA, Barendrecht AD, van Rijn BB, Brambilla R, van Tits LJ, Roest M. High-throughput genotyping with infrared fluorescence allele specific hybridization (iFLASH): A simple, reliable and low-cost alternative. Clin Biochem. 2006; 39(7): 739-45.
  • Van Rijn BB, Roest M, Franx A, Bruinse HW, Voorbij HA. Single step high-throughput determination of Toll-like receptor 4 polymorphisms. J Immunol Methods. 2004; 289(1-2): 81-7.
  • Sikkema JM, van Rijn BB, Franx A, Bruinse HW, de Roos R, Stroes ES, van Faassen EE. Placental superoxide is increased in pre-eclampsia. Placenta. 2001; 22(4): 304-8.


Presentatie(s) van deze spreker

vrijdag 29 november 2013 om 9:30 - 10:00

Pre-eclampsie en het lange-termijn risico op hart- en vaatziekten

Dr. B. Rijn van